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Article

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death.

Brain : a journal of neurology - 1 Oct 2017

Thiepold Anna-Luisa, Lorenz Nadja I, Foltyn Martha, Engel Anna L, Divé Iris, Urban Hans, Heller Sonja, Bruns Ines, Hofmann Ute, Dröse Stefan, Harter Patrick N, Mittelbronn Michel, Steinbach Joachim P, Ronellenfitsch Michael W

Abstract excerpt

Glioblastomas are characterized by fast uncontrolled growth leading to hypoxic areas and necrosis. Signalling from EGFR via mammalian target of rapamycin complex 1 (mTORC1) is a major driver of cell growth and proliferation and one of the most commonly altered signalling pathways in glioblastomas. Therefore, epidermal growth factor receptor and mTORC1 signalling are plausible therapeutic targets and clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28969371
DOI: 10.1093/brain/awx196

Genes

EGFR
PGC
TSC2
VEGFA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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