Article
Naturally Occurring Single Amino Acid Substitution in the L1 Major Capsid Protein of Human Papillomavirus Type 16: Alteration of Susceptibility to Antibody-Mediated Neutralization.
The Journal of infectious diseases - 17 Oct 2017
Ning Tingting, Wolfe Aaron, Nie Jianhui, Huang Weijin, Chen Xiaojiang S, Wang Youchun
Abstract excerpt
Background: Each vaccine for human papillomavirus type 16 (HPV16) has been developed on the basis of a single variant, and whether these vaccines can prevent infection due to naturally occurring variants was not clear. Methods: To examine this question, constructs of 39 naturally occurring single amino acid substitutions in L1 were generated for pseudovirion production, based on the analysis of 1204 HPV16 L1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.