Article
Natural variants in the major neutralizing epitope of human papillomavirus minor capsid protein L2.
International journal of cancer - 1 Feb 2013
Seitz Hanna, Schmitt Markus, Böhmer Gerd, Kopp-Schneider Annette, Müller Martin
Abstract excerpt
The amino terminus of the human papillomavirus minor capsid protein L2 contains a major cross-neutralizing epitope that provides the basis for the development of a broadly protective HPV vaccine. This attainable broad protection would eliminate one of the major drawbacks of the commercial L1-based prophylactic vaccines. In this study, we asked whether there are natural variants of the L2 cross-neutralizing...
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