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Article

Inflammasome gene expression is associated with immunopathology in human localized cutaneous leishmaniasis

20 Apr 2019

Abstract excerpt

Localized cutaneous leishmaniasis (LCL) can ultimately progress to chronic ulcerated lesions with strong local inflammatory reactions. The functional role of certain inflammasomes in mediating inflammation caused by Leishmania braziliensis needs to be addressed. By combining PCR-array, quantitative real-time PCR and immunohistochemical analysis, we identified inflammasome genes, such as IL-1β, NLRP3, NLRP1,...

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PMID: 31078283
DOI: 10.1016/j.cellimm.2019.04.008

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