Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.

doi:10.1016/j.molmed.2007.05.003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.

Trends in molecular medicine - 1 Jul 2007

Meaney Michael J, Szyf Moshe, Seckl Jonathan R

Abstract excerpt

Environmental effects on the materno-foetal interaction determine birth outcomes that predict health over the lifespan. Thus, maternal undernutrition or stress associate with low birth weight, leading to an increased risk of metabolic and cardiovascular illness in the offspring. We argue that these effects are, in part, mediated by direct and indirect effects on the hypothalamic-pituitary-adrenal (HPA) axis such...

Topics

11-beta-Hydroxysteroid Dehydrogenase Type 2
Adrenal Glands
Animals
Chromatin
DNA Methylation
Disease
Epigenesis, Genetic
Female
Fetal Development
Fetus
Glucocorticoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hypothalamo-Hypophyseal System

Infant, Low Birth Weight

Infant, Newborn

Maternal-Fetal Exchange

Phenotype

Pituitary-Adrenal System

Source

Open in PubMed

Identifiers

PMID: 17544850
DOI: 10.1016/j.molmed.2007.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.PMID 17544850Read ↗

Maternal influences on epigenetic programming of the developing hypothalamic‐pituitary‐adrenal axisSemantic proximity Read ↗

Developmental programming of the HPA axis and related behaviours: epigenetic mechanismsSemantic proximity Read ↗

Fetal programming and fetal psychologySemantic proximity Read ↗

Prenatal programming of stress responsiveness and behaviours: Progress and perspectivesSemantic proximity Read ↗

Incorporating epigenetic mechanisms to advance fetal programming theories.Semantic proximity Read ↗

Epigenetic responses and the developmental origins of health and diseaseSemantic proximity Read ↗

Perinatal stress and epigenetics.Semantic proximity Read ↗

Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment.Semantic proximity Read ↗

Fetal Growth and Intrauterine Epigenetic Programming of Obesity and Cardiometabolic DiseaseSemantic proximity Read ↗

Behavioral epigenetics and the developmental origins of child mental health disorders.Semantic proximity Read ↗

Fetal Programming of Body Composition, Obesity, and Metabolic Function: The Role of Intrauterine Stress and Stress BiologySemantic proximity Read ↗

Developmental programming of health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.