Article
Presence of new mutations in the TP53 gene in patients with low-risk myelodysplastic syndrome: two case reports.
Journal of medical case reports - 21 May 2017
Duarte Fernando Barroso, Lemes Romélia Pinheiro Gonçalves, Dos Santos Talyta Ellen de Jesus, Barbosa Maritza Cavalcante, de Vasconcelos João Paulo Leitão, Rocha-Filho Francisco Dário, Zalcberg Ilana, Coutinho Diego, Figueiredo Monalisa Feliciano, Carlos Luciana Barros, de Vasconcelos Paulo Roberto Leitão
Abstract excerpt
BACKGROUND: Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present...
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