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Article

Polygenic loading for major depression is associated with specific medical comorbidity.

Translational psychiatry - 19 Sept 2017

McCoy T H, Castro V M, Snapper L, Hart K, Januzzi J L, Huffman J C, Perlis R H

Abstract excerpt

Major depressive disorder frequently co-occurs with medical disorders, raising the possibility of shared genetic liability. Recent identification of 15 novel genetic loci associated with depression allows direct investigation of this question. In cohorts of individuals participating in biobanks at two academic medical centers, we calculated polygenic loading for risk loci reported to be associated with...

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Identifiers

PMID: 28926002
DOI: 10.1038/tp.2017.201
PMCID: PMC5639245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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