Article
Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.
British journal of cancer - 8 Jun 2010
Paraiso K H T, Fedorenko I V, Cantini L P, Munko A C, Hall M, Sondak V K, Messina J L, Flaherty K T, Smalley K S M
Abstract excerpt
BACKGROUND: Resistance to BRAF inhibitors is an emerging problem in the melanoma field. Strategies to prevent and overcome resistance are urgently required. METHODS: The dynamics of cell signalling, BrdU incorporation and cell-cycle entry after BRAF inhibition was measured using flow cytometry and western blot. The ability of combined BRAF/MEK inhibition to prevent the emergence of resistance was demonstrated by...
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