Article
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow.
The Journal of experimental medicine - 26 Oct 2009
Morikawa Satoru, Mabuchi Yo, Kubota Yoshiaki, Nagai Yasuo, Niibe Kunimichi, Hiratsu Emi, Suzuki Sadafumi, Miyauchi-Hara Chikako, Nagoshi Narihito, Sunabori Takehiko, Shimmura Shigeto, Miyawaki Atsushi, Nakagawa Taneaki, Suda Toshio, Okano Hideyuki, Matsuzaki Yumi
Abstract excerpt
Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth and can give rise to multiple mesenchymal lineages. Because MSCs have only been isolated from tissue in culture, the equivalent cells have not been identified in vivo and little is known about their physiological roles or even their exact tissue location. In this study, we used phenotypic, morphological, and functional...
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