Article
Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume.
Acta biomaterialia - 1 Nov 2017
Ghuman Harmanvir, Gerwig Madeline, Nicholls Francesca J, Liu Jessie R, Donnelly Julia, Badylak Stephen F, Modo Michel
Abstract excerpt
Salvaging or functional replacement of damaged tissue caused by stroke in the brain remains a major therapeutic challenge. In situ gelation and retention of a hydrogel bioscaffold composed of 8mg/mL extracellular matrix (ECM) can induce a robust invasion of cells within 24h and potentially promote a structural remodeling to replace lost tissue. Herein, we demonstrate a long-term retention of ECM hydrogel within...
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