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Article

MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells.

Cell cycle (Georgetown, Tex.) - 18 Oct 2017

Wang Lixia, Su Jingna, Zhao Zhe, Hou Yingying, Yin Xuyuan, Zheng Nana, Zhou Xiuxia, Yan Jingzhe, Xia Jun, Wang Zhiwei

Abstract excerpt

Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) in glioma. However, the underlying mechanism of chemotherapy-triggered EMT has not been fully understood. In the current study, we determined the role of miR-26b in regulation of EMT in stable temozolomide (TMZ)-resistant (TR) glioma cells, which have displayed mesenchymal...

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Identifiers

PMID: 28898169
DOI: 10.1080/15384101.2017.1367071
PMCID: PMC5638394

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