Article
T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model.
Scientific reports - 11 Sept 2017
Zhang Chuanshan, Shao Yingmei, Yang Shuting, Bi Xiaojuan, Li Liang, Wang Hui, Yang Ning, Li Zhide, Sun Cheng, Li Liang, Lü Guodong, Aji Tuerganaili, Vuitton Dominique A, Lin Renyong, Wen Hao
Abstract excerpt
The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to the parasite load. We demonstrated that local cellular immunity and fibrogenesis are actually protective and fully able to limit metacestode growth in the...
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