Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

doi:10.1016/j.leukres.2017.08.006

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Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

Leukemia research - 1 Oct 2017

Sakihama Shugo, Saito Mineki, Kuba-Miyara Megumi, Tomoyose Takeaki, Taira Naoya, Miyagi Takashi, Hayashi Masaki, Kinjo Shigeko, Nakachi Sawako, Tedokon Iori, Nishi Yukiko, Tamaki Keita, Morichika Kazuho, Uchihara Jun-Nosuke, Morishima Satoko, Karube Ken-Nosuke, Tanaka Yuetsu, Masuzaki Hiroaki, Fukushima Takuya

Abstract excerpt

Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB...

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PMID: 28866351
DOI: 10.1016/j.leukres.2017.08.006

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