Article
A genetic variant in the placenta-derived MHC class I chain-related gene A increases the risk of preterm birth in a Chinese population.
Human genetics - 1 Oct 2017
Song Junjiao, Li Jing, Liu Han, Gan Yuexin, Sun Yang, Yu Min, Zhang Yongjun, Luo Fei, Tian Ying, Wang Weiye, Zhang Jun, Little Julian, Cheng Haidong, Chen Dan
Abstract excerpt
Preterm birth (PTB) is a predominant contributor to neonatal mortality and morbidity worldwide. However, the pathophysiology of PTB is not well-understood. We tested the hypothesis that single-nucleotide polymorphisms (SNPs) in the placenta-derived MHC class I chain-related gene A (MICA) could disrupt placental development and hence result in PTB. Nineteen selected SNPs in MICA were genotyped in a case-control...
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