Article
Genotypic characterization directly applied to sputum improves the detection of Mycobacterium africanum West African 1, under-represented in positive cultures.
PLoS neglected tropical diseases - 1 Sept 2017
Sanoussi C N'Dira, Affolabi Dissou, Rigouts Leen, Anagonou Séverin, de Jong Bouke
Abstract excerpt
BACKGROUND: This study aimed to compare the prevalence of Mycobacterium tuberculosis complex (MTBc) lineages between direct genotyping (on sputum) and indirect genotyping (on culture), to characterize potential culture bias against difficult growers. METHODOLOGY/PRINCIPAL FINDINGS: Smear-positive sputa from consecutive new tuberculosis patients diagnosed in Cotonou, (Benin) were included, before patients had...
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