Article
Protein abundances can distinguish between naturally-occurring and laboratory strains of Yersinia pestis, the causative agent of plague.
PloS one - 1 Jan 2017
Merkley Eric D, Sego Landon H, Lin Andy, Leiser Owen P, Kaiser Brooke L Deatherage, Adkins Joshua N, Keim Paul S, Wagner David M, Kreuzer Helen W
Abstract excerpt
The rapid pace of bacterial evolution enables organisms to adapt to the laboratory environment with repeated passage and thus diverge from naturally-occurring environmental ("wild") strains. Distinguishing wild and laboratory strains is clearly important for biodefense and bioforensics; however, DNA sequence data alone has thus far not provided a clear signature, perhaps due to lack of understanding of how...
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