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Article

Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis.

Genome research - 1 Sept 2003

Hinchliffe Stewart J, Isherwood Karen E, Stabler Richard A, Prentice Michael B, Rakin Alexander, Nichols Richard A, Oyston Petra C F, Hinds Jason, Titball Richard W, Wren Brendan W

Abstract excerpt

Yersinia pestis, the causative agent of plague, diverged from Yersinia pseudotuberculosis, an enteric pathogen, an estimated 1500-20,000 years ago. Genetic characterization of these closely related organisms represents a useful model to study the rapid emergence of bacterial pathogens that threaten mankind. To this end, we undertook genome-wide DNA microarray analysis of 22 strains of Y. pestis and 10 strains of...

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Identifiers

PMID: 12952873
DOI: 10.1101/gr.1507303
PMCID: PMC403674

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