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Article

Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis.

Scientific reports - 29 Aug 2017

Huang Hui, Wang Yongjun, Cao Yong, Wu Boda, Li Yonggui, Fan Liangliang, Tan Zhiping, Jiang Yi, Tang Jianguang, Hu Jianzhong, Shi Xiaoliu

Abstract excerpt

Pachydermoperiostosis (PDP) is a rare inherited multisystem disease characterized with digital clubbing, pachydermia and periostosis. Variants in either HPGD or SLCO2A1 that interrupt the prostaglandin E2 (PGE2) pathway have been shown to be involved in PDP. Here, in addition to six confirmed variants in HPGD or SLCO2A1, we identified four novel SLCO2A1 variants in eight PDP patients from seven Chinese Han...

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Identifiers

PMID: 28851954
DOI: 10.1038/s41598-017-09671-7
PMCID: PMC5574921

Genes

HPGD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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