Identification of two novel mutations in the SLCO2A1 prostaglandin transporter gene in a Chinese patient with primary hypertrophic osteoarthropathy.

doi:10.3892/mmr.2017.6391

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Identification of two novel mutations in the SLCO2A1 prostaglandin transporter gene in a Chinese patient with primary hypertrophic osteoarthropathy.

Molecular medicine reports - 1 May 2017

Guo Ting, Yang Kai, Liu Lv, Tan Zhi-Ping, Luo Hong

Abstract excerpt

Primary hypertrophic osteoarthropathy (PHO), which is a rare multi‑organic disease characterized by digital clubbing, pachydermia and periosteal reaction, typically begins during childhood or adolescence and progresses gradually over years prior to disease stabilization. To date, only two genes have been reported to be associated with PHO, 15‑hydroxyprostaglandin dehydrogenase and solute carrier organic anion...

Topics

Adult
Amino Acid Sequence
Animals
Asian People
Base Sequence
China
DNA Mutational Analysis
Exons
Female
Genotype
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intramolecular Oxidoreductases

Isomerases

Male

Middle Aged

Mutation, Missense

Organic Anion Transporters

Source

Open in PubMed Open full text

Identifiers

PMID: 28339061
DOI: 10.3892/mmr.2017.6391
PMCID: PMC5428898

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Identification of two novel mutations in the SLCO2A1 prostaglandin transporter gene in a Chinese patient with primary hypertrophic osteoarthropathy.PMID 28339061Read ↗

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