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Article

Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle.

Scientific reports - 23 Aug 2017

Xiang Ruidong, MacLeod Iona M, Bolormaa Sunduimijid, Goddard Michael E

Abstract excerpt

While single nucleotide polymorphisms (SNPs) associated with multiple phenotype have been reported, the knowledge of pleiotropy of uncorrelated phenotype is minimal. Principal components (PCs) and uncorrelated Cholesky transformed traits (CT) were constructed using 25 raw traits (RTs) of 2841 dairy bulls. Multi-trait meta-analyses of single-trait genome-wide association studies for RT, PC and CT in bulls were...

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Identifiers

PMID: 28835686
DOI: 10.1038/s41598-017-09788-9
PMCID: PMC5569018

Genes

CAPN1
CAST
CSN2
DGAT1
GHR
GPAT4
MGST1
MUC1
PAEP
SDC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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