Article
A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks.
Applied and environmental microbiology - 1 Nov 2017
Buultjens Andrew H, Chua Kyra Y L, Baines Sarah L, Kwong Jason, Gao Wei, Cutcher Zoe, Adcock Stuart, Ballard Susan, Schultz Mark B, Tomita Takehiro, Subasinghe Nela, Carter Glen P, Pidot Sacha J, Franklin Lucinda, Seemann Torsten, Gonçalves Da Silva Anders, Howden Benjamin P, Stinear Timothy P
Abstract excerpt
Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative bacterium (Legionella pneumophila) has an unusual population structure, with extreme temporal and spatial genome sequence conservation. Furthermore, Legionnaires' disease outbreaks can be caused by multiple L. pneumophila genotypes in a single source. These factors can confound cluster...
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