Article
Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy.
Clinical pharmacokinetics - 1 Jun 2018
Peigné Sophie, Chhun Stéphanie, Tod Michel, Rey Elisabeth, Rodrigues Christelle, Chiron Catherine, Pons Gérard, Jullien Vincent
Abstract excerpt
AIM: The aim of this study was to describe the pharmacokinetics of stiripentol in children with Dravet syndrome and to determine the concentrations of stiripentol achieved in this population for the usual 25 mg/kg twice-daily dose. METHODS: Thirty-five children with epilepsy were included in a prospective population pharmacokinetic study (using MONOLIX software). Four blood samples were drawn per patient....
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