Article
Valuable antibody detection method for classifying hepatitis E virus genotypes.
Journal of medical virology - 1 Jan 2018
Zhao Chenyan, Geng Yansheng, Huang Weijing, Ma Hongxia, Wang Youchun
Abstract excerpt
Nucleotide-based methods are conventionally used to classify the hepatitis E virus (HEV) genotypes. A serological enzyme immunoassay (EIA) using open reading frame 3 (ORF3) C-terminal peptides was developed to conveniently and accurately classify and evaluate the genotypes of HEV. The sera of mice immunized with HEV genotype 1, 3, and 4 reacted highly specifically to the peptides of the corresponding genotypes....
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