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Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

9 Aug 2017

Abstract excerpt

Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methylated CpGs and replicated them in two independent Danish cohorts. The double-replicated CpGs were characterized by...

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PMID: 28811542
DOI: 10.1038/s41598-017-08346-7

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