Article
Targeted therapies in Acute Myeloid Leukemia: a focus on FLT-3 inhibitors and ABT199.
Expert review of hematology - 1 Oct 2017
Naqvi Kiran, Konopleva Marina, Ravandi Farhad
Abstract excerpt
INTRODUCTION: Acute myeloid leukemia (AML) remains a therapeutic challenge. Despite ongoing research, the standard therapy for AML has not changed significantly in the past four decades. With the identification of cytogenetic and molecular abnormalities, several promising therapeutic agents are c...
Topics
- Antineoplastic Agents
- Antineoplastic Combined Chemotherapy Protocols
- Biomimetics
- Bridged Bicyclo Compounds, Heterocyclic
- Clinical Trials as Topic
- Drug Resistance, Neoplasm
- Humans
- Leukemia, Myeloid, Acute
- Molecular Targeted Therapy
- Mutation
- Peptide Fragments
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins
- Signal Transduction
- Sulfonamides
- fms-Like Tyrosine Kinase 3