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The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible

4 Aug 2017

Abstract excerpt

There is epidemiological evidence that H. pylori might predispose to Alzheimer's disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the...

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PMID: 28798312
DOI: 10.1038/s41598-017-07532-x

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