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Article

Orion: Detecting regions of the human non-coding genome that are intolerant to variation using population genetics.

PloS one - 1 Jan 2017

Gussow Ayal B, Copeland Brett R, Dhindsa Ryan S, Wang Quanli, Petrovski Slavé, Majoros William H, Allen Andrew S, Goldstein David B

Abstract excerpt

There is broad agreement that genetic mutations occurring outside of the protein-coding regions play a key role in human disease. Despite this consensus, we are not yet capable of discerning which portions of non-coding sequence are important in the context of human disease. Here, we present Orion, an approach that detects regions of the non-coding genome that are depleted of variation, suggesting that the...

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Identifiers

PMID: 28797091
DOI: 10.1371/journal.pone.0181604
PMCID: PMC5552289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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