Article
Mutations in the novel gene FOPV are associated with familial autosomal dominant and non-familial obliterative portal venopathy.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2018
Besmond Claude, Valla Dominique, Hubert Laurence, Poirier Karine, Grosse Brigitte, Guettier Catherine, Bernard Olivier, Gonzales Emmanuel, Jacquemin Emmanuel
Abstract excerpt
BACKGROUND & AIMS: Obliterative portal venopathy (OPV) is characterized by lesions of portal vein intrahepatic branches and is thought to be responsible for many cases of portal hypertension in the absence of cirrhosis or obstruction of large portal or hepatic veins. In most cases the cause of OPV remains unknown. The aim was to identify a candidate gene of OPV. METHODS: Whole exome sequencing was performed in...
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