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Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

8 Aug 2017

Abstract excerpt

BACKGROUND: Sequence-specific PCR is the most common approach for virus identification in diagnostic laboratories. However, as specific PCR only detects pre-defined targets, novel virus strains or viruses not included in routine test panels will be missed. Recently, advances in high-throughput sequencing allow for virus-sequence-independent identification of entire virus populations in clinical samples, yet...

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PMID: 28789678
DOI: 10.1186/s40168-017-0317-z

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