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Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency

8 Jul 2017

Abstract excerpt

Ex vivo gene therapy using lentiviral vectors (LVs) is a proven approach to treat and potentially cure many hematologic disorders and malignancies but remains stymied by cumbersome, cost-prohibitive, and scale-limited production processes that cannot meet the demands of current clinical protocols for widespread clinical utilization. However, limitations in LV manufacture coupled with inefficient transduction...

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PMID: 28780274
DOI: 10.1016/j.ymthe.2017.07.002

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