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Article

Epigenetic silencing of LPP/miR-28 in multiple myeloma

3 Aug 2017

Abstract excerpt

AIMS: miR-28-5- is a tumour suppressor microRNA implicated in cancers. As a CpG island is absent in miR-28-5- but present in its host gene, LPP (LIM domain containing preferred translocation partner in lipoma), we hypothesized that miR-28-5p is epigenetically silenced by promoter DNA methylation of its host gene in multiple myeloma. METHODS: Methylation-specific PCR, verified by quantitative bisulfite...

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Identifiers

PMID: 28775176
DOI: 10.1136/jclinpath-2017-204501

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