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Article

The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186.

The Journal of biological chemistry - 15 Sept 2017

Wang Yuan, Chen Fuquan, Zhao Man, Yang Zhe, Li Jiong, Zhang Shuqin, Zhang Weiying, Ye Lihong, Zhang Xiaodong

Abstract excerpt

The long noncoding RNA highly up-regulated in liver cancer (HULC) is aberrantly elevated in hepatocellular carcinoma (HCC), and this up-regulation is crucial for HCC pathogenesis. However, the underlying mechanism in HULC up-regulation is poorly understood. We hypothesized that HULC might modulate the oncogene high mobility group A2 (HMGA2) to promote hepatocarcinogenesis. Quantitative real-time PCR analysis...

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Identifiers

PMID: 28765279
DOI: 10.1074/jbc.M117.783738
PMCID: PMC5602398

Genes

HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186.PMID 28765279Read ↗

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