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Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18

8 Jun 2012

Abstract excerpt

Long noncoding RNAs (lncRNAs) play crucial roles in human cancers. It has been reported that lncRNA highly up-regulated in liver cancer (HULC) is dramatically up-regulated in hepatocellular carcinoma (HCC). Hepatitis B virus X protein (HBx) contributes importantly to the development of HCC. However, the function of HULC in HCC mediated by HBx remains unclear. Here, we report that HULC is involved in HBx-mediated...

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PMID: 22685290
DOI: 10.1074/jbc.m112.342113

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Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18PMID 22685290Read ↗

Involvement of long non-coding RNA HULC (highly up-regulated in liver cancer) in pathogenesis and implications for therapeutic interventionSemantic proximity Read ↗

Long noncoding RNA HULC regulates the NF‐κB pathway and represents a promising prognostic biomarker in liver cancerSemantic proximity Read ↗

High expression of long noncoding RNA HULC is a poor predictor of prognosis and regulates cell proliferation in gliomaSemantic proximity Read ↗

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Long Noncoding RNA Highly Upregulated in Liver Cancer Activates p53-p21 Pathway and Promotes Nasopharyngeal Carcinoma Cell GrowthSemantic proximity Read ↗

LncRNA HULC shRNA disinhibits miR-377-5p to suppress the growth and invasion of hepatocellular carcinoma in vitro and hepatocarcinogenesis in vivoSemantic proximity Read ↗

Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagySemantic proximity Read ↗

The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186.Semantic proximity Read ↗

Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15aSemantic proximity Read ↗

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Long noncoding RNA LIPH-4 promotes esophageal squamous cell carcinoma progression by regulating the miR-216b/IGF2BP2 axisSemantic proximity Read ↗

LncRNA HULC affects the differentiation of Treg in HBV-related liver cirrhosisSemantic proximity Read ↗

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