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Article

Application of phospho-CyTOF to characterize immune activation in patients with sickle cell disease in an ex vivo model of thrombosis.

Journal of immunological methods - 1 Feb 2018

Glassberg Jeffrey, Rahman Adeeb H, Zafar Mohammad, Cromwell Caroline, Punzalan Alexa, Badimon Juan Jose, Aledort Louis

Abstract excerpt

Sickle cell disease (SCD) is a genetic disease caused by mutations in the beta globin gene, and inflammation plays a key role in driving many aspects of disease pathology. Early immune activation is believed to be associated with hemodynamic stresses and thrombus formation as cells traffic through blood vessels. We applied an extracorporeal perfusion system to model these effects ex vivo, and combined this with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28760671
DOI: 10.1016/j.jim.2017.07.014
PMCID: PMC7487207

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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