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Article

Molecular Dynamics Simulations of Quinolone Resistance-Associated T86I and P104S Mutations in Campylobacter jejuni gyrA: Unraveling Structural Repercussions.

Microbial drug resistance (Larchmont, N.Y.) - 1 Apr 2018

Mehla Kusum, Ramana Jayashree

Abstract excerpt

gyrA is a clinically validated therapeutic drug target that catalyzes changes in DNA topology by introducing negative supercoils into DNA. The broad-spectrum quinolones are hitherto the most potent antibacterial agents targeted toward gyrA. Increasing resistance to quinolones is accompanied by several mutations in the quinolone resistance-determining region of gyrA. In the present study, we report a comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28759328
DOI: 10.1089/mdr.2017.0020

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