Article
Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study.
Oral surgery, oral medicine, oral pathology and oral radiology - 1 Aug 2017
Bates Amber M, Lanzel Emily A, Qian Fang, Abbasi Taher, Vali Shireen, Brogden Kim A
Abstract excerpt
OBJECTIVES: Programmed death-ligand 1 (PD-L1) expression is correlated with objective response rates to PD-1 and PD-L1 immunotherapies. However, both immunotherapies have only demonstrated 12%-24.8% objective response rates in patients with head and neck squamous cell carcinoma (HNSCC), demonstrating a need for a more accurate method to identify those who will respond before their therapy. Immunohistochemistry to...
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