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Article

Molecular Subtypes Based on Cell Differentiation Trajectories in Head and Neck Squamous Cell Carcinoma: Differential Prognosis and Immunotherapeutic Responses.

Frontiers in immunology - 1 Jan 2021

Huang Zhen-Dong, Liu Zi-Zhen, Liu Yan-Yi, Fu Yong-Cheng, Lin Lu-Lu, Hu Chao, Gu Hui-Yun, Wei Ren-Xiong

Abstract excerpt

Objective: Head and neck squamous cell carcinoma (HNSCC) is one of the most common and lethal malignant tumors. We aimed to investigate the HNSCC cell differentiation trajectories and the corresponding clinical relevance. Methods: Based on HNSCC cell differentiation-related genes (HDRGs) identified by single-cell sequencing analysis, the molecular subtypes and corresponding immunity, metabolism, and stemness...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35003112
DOI: 10.3389/fimmu.2021.791621
PMCID: PMC8739483

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