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Article

Association of combined GIF290T>C heterozygous mutation/FUT2 secretor variant with neural tube defects.

Clinical genetics - 1 Jan 2018

Guéant-Rodriguez R M, Chery C, Caillierez-Fofou B-M, Voirin J, Foliguet B, Josse T, Tramoy D, Feillet F, Guéant J-L

Abstract excerpt

Folate and vitamin B12 are needed for the proper embryo-fetal development possibly through their interacting role in the 1-carbon metabolism. Folate fortification reduces the prevalence of complex birth defects, and more specifically neural tube defects (NTDs). GIF and FUT2 are 2 genes associated with the uptake and blood level of vitamin B12. We evaluated GIF and FUT2 as predictors of severe birth defects, in...

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Source

Identifiers

PMID: 28742214
DOI: 10.1111/cge.13104

Genes

FUT2
CUBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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