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Article

Associations between gastric dilatation-volvulus in Great Danes and specific alleles of the canine immune-system genes DLA88, DRB1, and TLR5.

American journal of veterinary research - 1 Aug 2017

Harkey Michael A, Villagran Alexandra M, Venkataraman Gopalakrishnan M, Leisenring Wendy M, Hullar Meredith A J, Torok-Storb Beverly J

Abstract excerpt

OBJECTIVE To determine whether specific alleles of candidate genes of the major histocompatibility complex (MHC) and innate immune system were associated with gastric dilatation-volvulus (GDV) in Great Danes. ANIMALS 42 healthy Great Danes (control group) and 39 Great Danes with ≥ 1 GDV episode. PROCEDURES Variable regions of the 2 most polymorphic MHC genes (DLA88 and DRB1) were amplified and sequenced from the...

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Source

Identifiers

PMID: 28738011
DOI: 10.2460/ajvr.78.8.934

Genes

TLR5
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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