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Article

An In Vitro Model for the Ocular Surface and Tear Film System

17 Jul 2017

Abstract excerpt

Dry eye is a complicated ocular surface disease whose exact pathogenesis is not yet fully understood. For the therapeutic evaluation and pathogenesis study of dry eye, we established an in vitro three-dimensional (3D) coculture model for the ocular surface. It is composed of rabbit conjunctival epithelium and lacrimal gland cell spheroids, and recapitulates the aqueous and mucin layers of the tear film. We first...

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PMID: 28733649
DOI: 10.1038/s41598-017-06369-8

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