Article
The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women.
The Journal of international medical research - 1 Jan 2018
Xu Tianyi, Shi Yiru, Liu Jiangbo, Liu Yun, Zhu Ailin, Xie Cui, Zhang Yan, Chen Yan, Ren Lirong
Abstract excerpt
Objective The rs10229583 polymorphism near paired box gene 4 ( PAX4) is associated with insulin resistance and type 2 diabetes. Mutations in the PAX4 gene may be associated with impaired differentiation/development of pancreatic islet beta cells during fetal development and, consequently, a compromised insulin response to high blood glucose. To ascertain whether this polymorphism plays a role in gestational...
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