Article
Molecular analysis of BRCA1 and BRCA2 genes by next generation sequencing and ultrastructural aspects of breast tumor tissue.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie - 1 Jan 2017
Mihalcea Corina Elena, Moroşanu Ana Maria, Murăraşu Daniela, Puiu Liliana, Cinca Sabin Aurel, Voinea Silviu Cristian, Mirancea Nicolae
Abstract excerpt
In this paper, we focus our interest on the dynamics alterations of the tumor-stroma interface at the ultrastructural level and to detect BRCA1 and BRCA2 mutations using next generation sequencing (NGS) of breast tumor tissue. Electron microscopic investigation revealed some peculiar infrastructural alterations of the tumor cells per se as well as of the tumor-stroma interface: invadopodia, shedding...
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