Article
Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.
Molecular cancer research : MCR - 1 Oct 2017
Li Chenggang, Liu Xiaolei, Liu Yang, Zhang Erik, Medepalli Kantha, Masuda Kouhei, Li Na, Wikenheiser-Brokamp Kathryn A, Osterburg Andrew, Borchers Michael T, Kopras Elizabeth J, Plas David R, Sun Julia, Franz David N, Capal Jamie K, Mays Maxwell, Sun Yang, Kwiatkowski David J, Alayev Anya, Holz Marina K, Krueger Darcy A, Siroky Brian J, Yu Jane J
Abstract excerpt
Tuberous sclerosis complex (TSC) is a tumor-suppressor syndrome affecting multiple organs, including the brain, skin, kidneys, heart, and lungs. TSC is associated with mutations in TSC1 or TSC2, resulting in hyperactivation of mTOR complex 1 (mTORC1). Clinical trials demonstrate that mTORC1 inhibitors decrease tumor volume and stabilize lung function in TSC patients; however, mTOR inhibitors are cytostatic not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.