Article
Band pattern analysis of mutations in rifampicin resistance strain of Mycobacterium tuberculosis by Line Probe assay in patients from Delhi, India.
The Indian journal of tuberculosis - 1 Jul 2017
Vashistha Himanshu, Hanif M, Chopra K K, Khanna Ashwani, Shrivastava Divya
Abstract excerpt
BACKGROUND: The GenoType MTBDRplus, a commercial Line Probe Assay (LPA) kit from Hain Lifescience, Germany, is endorsed by India's RNTCP Program for diagnosis of DRTB cases among smear-positive sputum samples. Although the LPA has been studied in several laboratories, there is a wide variation in existing M. tuberculosis strains across the globe, and false results can occur due to the presence of unique genetic...
Topics
- Antibiotics, Antitubercular
- Bacterial Proteins
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Drug Resistance, Multiple, Bacterial
- Ethambutol
- Humans
- India
- Isoniazid
- Microbial Sensitivity Tests
- Mutation
- Mycobacterium tuberculosis
- Rifampin