Article
CRISPR/Cas9 mediated genome editing of Helicoverpa armigera with mutations of an ABC transporter gene HaABCA2 confers resistance to Bacillus thuringiensis Cry2A toxins.
Insect biochemistry and molecular biology - 1 Aug 2017
Wang Jing, Wang Huidong, Liu Shaoyan, Liu Laipan, Tay Wee Tek, Walsh Thomas K, Yang Yihua, Wu Yidong
Abstract excerpt
High levels of resistance to Bt toxin Cry2Ab have been identified to be genetically linked with loss of function mutations of an ABC transporter gene (ABCA2) in two lepidopteran insects, Helicoverpa armigera and Helicoverpa punctigera. To further confirm the causal relationship between the ABCA2 gene (HaABCA2) and Cry2Ab resistance in H. armigera, two HaABCA2 knockout strains were created from the susceptible SCD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.