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Paracoccidioides brasiliensispresents metabolic reprogramming and secretes a serine proteinase during murine infection

13 Jul 2017

Abstract excerpt

Paracoccidoides brasiliensis and Paracoccidioides lutzii, the etiologic agents of paracoccidioidomycosis, cause disease in healthy and immunocompromised persons in Latin America. We developed a method for harvesting P. brasiliensis yeast cells from infected murine lung to facilitate in vivo transcriptional and proteomic profiling. P. brasiliensis harvested at 6 h post-infection were analyzed using RNAseq and...

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PMID: 28704618
DOI: 10.1080/21505594.2017.1355660

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