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Article

An autopsy case of Creutzfeldt-Jakob disease with a prion protein gene codon 180 mutation presenting with pathological laughing and an exaggerated startle reaction.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Dec 2017

Iwasaki Yasushi, Mori Keiko, Ito Masumi, Akagi Akio, Mimuro Maya, Kitamoto Tetsuyuki, Yoshida Mari

Abstract excerpt

A 78-year-old Japanese woman presented with slow progressive disorientation and memory disturbances. Pathological laughing was observed at an early disease stage and continued for several months. Around the same time, the patient began to exhibit an exaggerated startle reaction and mild myoclonus. The pathological laughing and startle reaction disappeared before the patient reached an akinetic mutism state...

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Identifiers

PMID: 28703419
DOI: 10.1111/neup.12399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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