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Article

SOX2 as a New Regulator of HPV16 Transcription

5 Jul 2017

Abstract excerpt

Persistent infections with high-risk human papillomavirus (HPV) constitute the main risk factor for cervical cancer development. HPV16 is the most frequent type associated to squamous cell carcinomas (SCC), followed by HPV18. The long control region (LCR) in the HPV genome contains the replication origin and sequences recognized by cellular transcription factors (TFs) controlling viral transcription. Altered...

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PMID: 28678184
DOI: 10.3390/v9070175

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