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Article

Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer.

Cancer chemotherapy and pharmacology - 1 Sept 2017

Mbatchi Litaty C, Gassiot Matthieu, Pourquier Philippe, Goberna Alejando, Mahammedi Hakim, Mourey Loic, Joly Florence, Lumbroso Serge, Evrard Alexandre, Houede Nadine

Abstract excerpt

PURPOSE: Temsirolimus is a mammalian target of rapamycin (mTOR) inhibitor that exhibits antitumor activity in renal cell carcinoma and mantle cell lymphoma. The metabolism of temsirolimus and its active metabolite sirolimus mainly depends on cytochrome P450 3A4/5 (CYP3A4/A5) and the ABCB1 transporter. Differently from sirolimus, no pharmacogenetic study on temsirolimus has been conducted. Therefore, the aim of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28676933
DOI: 10.1007/s00280-017-3379-5

Genes

ABCB1

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