Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease

26 Jun 2017

Abstract excerpt

Graft versus host disease (GVHD) represents a major complication of allogeneic hematopoietic stem cell transplantation (allo HCT). Graft cellular manipulation has been used to mitigate the risk of GVHD. The αβ T cells are considered the primary culprit for causing GVHD therefore depletion of this T cell subset emerged as a promising cellular manipulation strategy to overcome the human leukocyte antigen (HLA)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28672883
DOI: 10.3390/biomedicines5030035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of αβ T Cell Depletion in Prevention of Graft versus Host DiseasePMID 28672883Read ↗

Specific removal of alloreactive T-cells to prevent GvHD in hemopoietic stem cell transplantation: rationale, strategies and perspectivesSemantic proximity Read ↗

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disordersSemantic proximity Read ↗

Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficienciesSemantic proximity Read ↗

Defibrotide inhibits donor leucocyte‐endothelial interactions and protects against acute graft‐versus‐host diseaseSemantic proximity Read ↗

HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusionSemantic proximity Read ↗

Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppressionSemantic proximity Read ↗

Definition of a critical T cell threshold for prevention of GVHD after HLA non-identical PBPC transplantation in childrenSemantic proximity Read ↗

Haploidentical hematopoietic transplantation for the cure of leukemia: from its biology to clinical translationSemantic proximity Read ↗

Haploidentical transplantation for hematologic malignancies: where do we stand?Semantic proximity Read ↗

Granulocyte Colony-Stimulating Factor Effectively Mobilizes TCR γδ and NK Cells Providing an Allograft Potentially Enhanced for the Graft-Versus-Leukemia Effect for Allogeneic Stem Cell Transplantation.Semantic proximity Read ↗

Cyclophosphamide-Induced Tolerance in Allogeneic Transplantation: From Basic Studies to Clinical ApplicationSemantic proximity Read ↗

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.